PMS8 National Burden of Achondroplasia in Adults and Children: An Analysis of the National Inpatient Sample

Achondroplasia is a rare, genetic disorder of skeletal dysplasia with an estimated birth prevalence 4 per 100,000 in North America. People achondroplasia often experience complications requiring hospitalizations. Our objective was to estimate the cost hospital admissions for people US. Using 2017 data from National Inpatient Sample, discharge diagnosis consistent (ICD-10-CM code: Q77.4) any position were identified. Descriptive, weighted measures, including patient characteristics, length stay (LOS), and inpatient costs reported. Costs using charges each hospitalization cost-to-charge ratio included NIS. There 1,985 nationwide (1,080 adults 905 children). Mean (95% confidence interval [CI]) age 26.8 (24.0-29.6) years. About one-third (30.6% [24.4%-36.7%]) 31-49 years majority (69.1% [61.4%-76.8]) children 0-4 Medicare primary payer (45.4% [38.6%-52.2%]), Medicaid (49.7% [41.6%-57.8%]). The average LOS 6.8 (5.7-8.0) days, 6.6 (5.5-7.7) 7.1 (5.0-9.2) children. Total mean CI) $19,959 (16,801-23,118), $18,224 (15,157-21,292) $22,031 (16,311-27,752) total $19.7 million $19.9 Among procedure reported, 19.6% on spine, 10.9% extremities, 6.8% head neck, 3.0% brain, remainder other body parts. Despite rarity condition, burden alone high, approximately $40 2017. Compared general population, 2.2 days longer $7,789 higher achondroplasia.